High levels of stress are known to contribute to the development of many psychiatric and medical conditions, including depression, anxiety disorders, hypertension, and heart disease. Past case studies suggest that psychiatric disorders linked to stress exposure can manifest differently in men and women, with the two sexes often predominantly exhibiting different symptoms.
, identifies specific cell types that respond to stress exposure in males and females.
"For instance, taking depression as an example, we know that almost 2/3 of all depressed patients are women, but we also know that women and man patients develop different sets of symptoms, and they develop them at a different pace . However, we do not know the reasons at the molecule and cell level of why these differences exist."
Using single-cell RNA sequencing, the researchers tried to determine what cells were most sensitive to stress and affected by chronic stress conditions in the brain of male and female mice. They then compared their observations for the two sexes, to unveil similarities or differences between these stress-responsive cell types.
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