Females' and males' muscles differ in glucose and fatty acid handling – but regular physical activity quickly triggers similar beneficial metabolic changes in the muscles of both sexes, new research to be presented at this year's Annual Meeting of the European Association for the Study of Diabetes (EASD) (Madrid, 9-13 September) has found.
DiabetologiaAug 16 2024 Females' and males' muscles differ in glucose and fatty acid handling – but regular physical activity quickly triggers similar beneficial metabolic changes in the muscles of both sexes, new research to be presented at this year's Annual Meeting of the European Association for the Study of Diabetes has found.
To learn more, Dr Dreher and colleagues analysed the molecular differences in muscle biopsies from 9 males and 16 females. All were healthy, with an average age of 30 years, living with overweight or obesity and did not take part in regular sporting activities. At baseline, there were sex-related differences in levels of the RNA strands, or transcripts, in skeletal muscle associated with glucose homeostasis and insulin signalling .
The response to the first exercise session differed substantially between the untrained females and males, with the males' muscles showing much more evidence of cellular stress, suggesting the males' muscles found it more difficult to adapt to exercise than the females' muscles.
Blood Diabetes Exercise Food Glucose Hormone Insulin Lipids Muscle Obesity Pancreas Physical Activity Research RNA Type 2 Diabetes Weight Loss
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