Stronger defense: symptomatic malaria provides durable protection against reinfection PLOSPathogens DukeU malaria defense symptomatic asymptomatic reinfection protection
By Pooja Toshniwal PahariaJun 14 2023Reviewed by Lily Ramsey, LLM In a recent study published in the PLOS Pathogens Journal, researchers evaluated the immune protection conferred by symptomatic and asymptomatic Plasmodium falciparum infections against reinfection.
Capturing identical reinfection events and assessing their relationships with host and parasite variables can shed light on anti-parasite immunological memory induction mechanisms. The researchers investigated whether symptomaticity affected reinfection risks with parasitic organisms comprising homologous hematological apical membrane antigen 1 and pre-erythrocytic circumsporozoite protein types of epitopes.
Multivariable mixed effects Cox proportional hazards regression modeling was performed to calculate the adjusted hazard ratios for reinfection risks following symptomatic and asymptomatic P. falciparum infections. Symptomatic infections lowered reinfection risks by 30% to 40%, and the association between symptomatic malaria and homologous reinfection risks was most robust for rare epitopes. Assessing the genotypes of the causative infections showed 155 and 209 pfcsp and pfama nucleotide genetic sequences, respectively.
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