New research sheds light on symptoms of understudied spine disease
mice showed significant differences in the grip force, tail suspension, and flexmaze assays at earlier stages of spine calcification than did malemice. Since ectopic calcification was not different between female and male mice at any time point, these findings suggest that femalemice are more susceptible to discomfort or pain.
]. Although mechanisms underlying discomfort were not addressed in the current investigation, our results provide the foundation for the application of future targeted treatments to alleviate symptoms of and/or modify the progression of spine calcification in a preclinical model of DISH.All datasets generated or analyzed during this study are included in this published article.
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