Study shows chemical coatings can affect microparticles 'swimming' in mucus solutions smu SciReports
. For these reasons, many drug compounds often have biotin functional groups that allow them to attach to micro/nanoparticles or other delivery vehicles coated with avidin. Common drug treatments in the gastrointestinal tract often rely on mucoadhesive compounds, to both increase uptake of drug payloads and ensure correct localization of drug carrying nanoparticles.
This study investigates the effects commercially available biotinylated chemical coatings have on spontaneous symmetry breaking propulsion within a mucus solution. The chemical coatings selected for this investigation include the original avidin surface coating , a biotin-avidin complex [Case 2], a biotinylated polyethylene glycol amine [Case 3], and biotin chitosan [Case 3].
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