Spatial lung cell atlas offers insights into disease and immune function NatureGenet
, this freely available resource highlights multiple immune cells, barrier cells, and their environments in the lung that are implicated inThis new lung cell atlas, which is part of the wider international Human Cell Atlas Initiative, combined single cell sequencing with spatial transcriptomics to provide a fuller picture of how cells interact and communicate with each other.
In this study, researchers from the Wellcome Sanger Institute and collaborators, genetically profiled nearly 200,000 cells fromof 13 donors, discovering 11 new cell types, and showing the exact location of 80 cell types in total. Dr. Elo Madissoon, joint first author and Post-Doctoral Fellow at the Wellcome Sanger Institute and EMBL's European Bioinformatics Institute , said,"By being able to analyze multiple locations of the same lung, we were able to get key information about a range of cells in a single study, many of which were not previously mapped.
IgA responses are important for efficient protection against respiratory infections and are impaired in lung diseases, such as COPD and cystic fibrosis. Further research investigating GAIN function could help develop therapies to alleviate disease symptoms, improve resistance to infection or create ways to boost vaccine responses.
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