The party is tipped to win the vote, but with a reduced majority and the result will reveal whether its new leader, President Cyril Ramaphosa, can reverse growing resentment among South African voters.
Support for the ANC has fallen in every election since 2004 with the party winning just 54 percent in 2016 local elections, compared with 62 percent in the last national vote in 2014.
"The ANC will pull another majority. It might be a reduced majority," said political scientist Collette Schulz-Herzenberg from Stellenbosch University. The ANC has been confronted by deepening public anger over its failure to tackle poverty and inequality in post-apartheid South Africa.
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