This pooled analysis of five RCTs in RA found that 2 years of low-dose glucocorticoid treatment [7.5 mg/day or less] leads to a modest weight gain of about 1 kg but has no effect on BP.
Studies were combined for stronger results
To overcome these limitations, Dr. Palmowski and associates combined individual participant data from five RCTs of glucocorticoid treatment for RA in 12 countries in Europe. The 1,112 participants had early and established RA, averaged 61.4 years of age, and 68% were women. The , an RCT that contributed about 40% of the overall study population,"explicitly included elderly patients and patients with multimorbidity who are often excluded from RA trials," the authors wrote.
At 2 years, both groups gained weight, but participants who took glucocorticoids gained an average of 1.1 kg more than the controls. Mean arterial pressure increased by around 2 mm Hg in both groups, with a –0.4 mm Hg between-group difference time periods may have yielded additional findings," said Dr. Huffman, who also was not involved in the study."Efforts should be made to minimize long-term prednisone use to minimize impact on weight gain and resulting consequences.
Dr. Arkfeld would like to know whether early versus late RA patients may have different results because they may have different pathophysiologies.
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