Skipping nightly toothbrushing could heighten cardiovascular disease risk Toothbrushing Cardiovascular Health OralHygiene BrushAtNight HeartHealth CVDRisk Dental Teeth SciReports
By Neha MathurJul 2 2023Reviewed by Benedette Cuffari, M.Sc. In a recent study published in Scientific Reports, researchers determined whether the frequency of brushing one's teeth increases the risk of cardiovascular diseases in patients aged 20 years or older.
Many of these reports have focused on the time of tooth brushing in the context of demineralization of the teeth. However, these reports did not explore the relationship between toothbrush time and systemic diseases, including CVD. The number of participants in each group was 409, 751, 164, and 259, respectively. The number of men in group M was four times that of women in this group.
One dentist investigated oral health, pre-hospitalization frequency and time of toothbrushing, the depth of periodontal pockets, the extent of tooth mobility, and teeth count. Study findings Based on blood samples obtained at hospital admission, all participants had similar C-reactive protein , hemoglobin, albumin, creatinine, and HbA1c levels but different brain natriuretic peptide levels. Groups MN and Night had significantly higher survival rates as compared to Group None.
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Dysregulation of iron homeostasis in airways associated with persistent preschool wheezing - Respiratory ResearchBackground Currently, there are no reliable clinical tools available to identify persistent asthma symptoms among preschool children with recurrent wheezing. We investigated iron homeostasis in the airways of preschoolers with recurrent wheezing and assessed whether iron homeostasis-related indices may reliably predict persistent wheezing. Methods Iron levels and mRNA expression levels of iron homeostasis molecules were examined in bronchoalveolar lavage samples from 89 preschoolers with recurrent wheezing and 56 controls, with a 12-month follow-up conducted. Risk factors for persistent wheezing were identified using least absolute shrinkage and selection operator and multivariate logistic regression. The addition of predictive values of iron indices to the modified Asthma Predictive Index (mAPI) or clinical predictors was determined using area under receiver operating characteristic curves (AUC). Results Preschoolers with recurrent wheezing had reduced iron levels in their airways, associated with significantly decreased expression of iron export molecule SLC40A1 and increased expression of iron intake factor TFR1 and iron storage factors FTH and FTL. Risk factors for persistent wheezing included mAPI positivity, iron predictors (lower expression of SLC40A1 and higher expression of FTL), and clinical predictors (aeroallergen sensitivity, shorter breastfeeding duration, and earlier age of first wheezing episode). The addition of information on iron predictors significantly enhanced the power of clinical predictors (AUC: 84%, increase of 12%) and mAPI (AUC: 81%, increase of 14%). Conclusions Iron homeostasis is altered in the airways of preschoolers with recurrent wheezing. Adding information on iron-related indices to clinical information significantly improves accurate prediction of persistent wheezing in preschool-aged children.
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“They want you to know who they really are inside of the old visage”—biographical storytelling as a methodological tool to explore emotional challenges in old age - BMC GeriatricsBackground Growing older is often associated with resilience, contentedness and inner growth. Older people however are also at risk of confronting unique emotional challenges as a result of varied ageing-related experiences. By employing a biographical lens, we aim to introduce storytelling as a methodological tool to more holistically explore older people’s emotional challenges and to improve their wellbeing. Methods Building upon theoretical understandings about the narrative construction of identity across the life span, we draw upon a qualitative study about older people’s loneliness as an example to showcase the methodological value and feasibility of biographical storytelling. We aim to better understand the nuanced and sometimes painful emotional experiences that can be encountered alongside ageing. Results Findings from the qualitative study we showcase, highlight that unique emotional pains and the (in)ability to deal with such in old age could be deeply rooted in older people’s earlier lives. These findings contextualise people’s emotional challenges and needs within their identity, as a narrative thread that links their past, present and expected future. As such, our example study shows that emotional challenges in old age are not only ageing-related, but can be more fundamentally connected to disruptions to the ongoing flow of narrative identity construction. Conclusion The highly retrospective and reflexive nature of these findings illustrates the methodological merit of biographical storytelling. We argue that the impact of biographical storytelling can go further than both conventional semi-structured narrative interviews and existing interventional tools. Instead, it is a particularly useful research methodology to explore human experiences and needs in the unique context of ageing. This methodological development thus provides an insightful analytical lens to explore how older people’s earlier life experiences may be carried forward and confronted t
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Kylian Mbappe calls for calm as riots continue across France for a fourth nightMore than 40,000 officers have been sent into the streets in an effort to quell rioting following the fatal police shooting of a 17-year-old by police.
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