Detailed 3D modeling aided Rice scientists in enhancing the system's precision. Small and precise: These are the ideal characteristics for CRISPR systems, the Nobel-prize winning technology used to edit nucleic acids like RNA and DNA. Scientists from Rice University have described in detail the
Scientists have detailed the three-dimensional structure of one of the smallest known CRISPR-Cas13 systems, CRISPR-Cas13bt3, used for RNA modification, which operates differently from other proteins in the same family. This discovery allowed them to enhance the tool’s precision, enabling better access and delivery to target editing sites, holding promise for more effective virus combat by targeting RNA.
“We had to do a lot of troubleshooting to make the protein and RNA complex more stable, so we could map it,” Deng said. “We found that in cell cultures these systems were able to hone in on a target much easier,” said Sherry Gao, the Ted N. Law Assistant Professor of Chemical and Biomolecular Engineering. “What is really remarkable about this work is that the detailed structural biology insights enabled a rational determination of the engineering efforts needed to improve the tool’s specificity while still maintaining high on-target RNA editing activity.
South Africa Latest News, South Africa Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Our 10 Most Popular Recipes in SeptemberRice cake lasagna, marzipan bars, and much more.Rice cake lasagna, marzipan bars, and much more.
Read more »
Tiny CRISPR tool could help shred virusesScientists mapped out the three-dimensional structure of one of the smallest known CRISPR-Cas13 systems then used that knowledge to modify its structure and improve its accuracy.
Read more »
Oregon middle school won't say whether student filmed attacking smaller girl is transgenderAn Oregon middle school would not comment on whether a student who was charged for assaulting a smaller girl in a school hallway is transgender.
Read more »
Razer BlackWidow V4 75% Review: Smaller Mechanical Gaming Keyboard DeliversI came away incredibly impressed by the Razer BlackWidow V4 75% keyboard. It's the ideal mix of function, size, and comfort.
Read more »
Why the Rice's whale is creating a stir in CongressThe endangered marine species is the subject of a battle between environmentalists and the Biden Administration against Republicans who fret over the offshore oil and gas production.
Read more »
Daniels propels Rice to 24-17 victory over East CarolinaJT Daniels threw two touchdown passes, including the go-ahead score in the fourth quarter, and Rice held on for a 24-17 victory over East Carolina.
Read more »