SGLT2is lowered the risk of NAFLD and HCC in comparison with DPP4is. Study also found that SGLT2is were associated with lower risk of cancer-related mortality and all-cause mortality.
has been shown to protect against HCC, and there is interest in exploring the potential protective effects of newer glucose-lowering medications.The retrospective population-based cohort study, which included 62699 patients with T2D treated with either SGLT2i or DPP4i , was conducted in Hong Kong from 2015 to 2019. The cohorts were comparable after matching.Follow-up was through 2020; total follow-up included 236856.5 person-years.
After 239941.9 person-years of follow-up, the incidence of HCC was lower among SGLT2I users than among DPP4i users . Among SGLT2i users, the risk of cancer-related mortality was lower than among DPP4i users , as was the risk of all-cause mortality in comparison with DPP4i users . In multivariable models, the risk of NAFLD was lower among SGLT2i , HCC , cancer-related mortality and all-cause mortality after adjustments.The study was observational, and there was a potential for coding errors and missing data.Medication adherence could not be directly assessed.Drug exposure duration was not controlled.The authors have disclosed no relevant financial relationships.
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