Former Sex Pistols star John Lydon is competing to represent Ireland in the Eurovision Song Contest 2023 – yes, really 🤩
Public Image Ltd formed in London in 1978, with the first line-up of the band including bassist Jah Wobble and former Clash guitarist Keith Levene.
In 1987, a new line-up was formed consisting of Lydon, former Siouxsie and the Banshees guitarist John McGeoch, Allan Dias on bass guitar in addition to drummer Smith and Edmunds. Lydon, Dias and McGeoch were joined by Curt Bisquera on drums and Gregg Arreguin on rhythm guitar for the album That What Is Not, which featured the Tower of Power horns on two songs and Jimmie Wood on harmonica.After Lydon, McGeoch and Dias wrote the song Criminal for the film Point Break and released an album in 1993, Lydon put Public Image Ltd on indefinite hiatus.
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Sex differences in early and term placenta are conserved in adult tissues - Biology of Sex DifferencesBackground Pregnancy complications vary based on the fetus’s genetic sex, which may, in part, be modulated by the placenta. Furthermore, developmental differences early in life can have lifelong health outcomes. Yet, sex differences in gene expression within the placenta at different timepoints throughout pregnancy and comparisons to adult tissues remains poorly characterized. Methods Here, we collect and characterize sex differences in gene expression in term placentas (≥ 36.6 weeks; 23 male XY and 27 female XX). These are compared with sex differences in previously collected first trimester placenta samples and 42 non-reproductive adult tissues from GTEx. Results We identify 268 and 53 sex-differentially expressed genes in the uncomplicated late first trimester and term placentas, respectively. Of the 53 sex-differentially expressed genes observed in the term placentas, 31 are also sex-differentially expressed genes in the late first trimester placentas. Furthermore, sex differences in gene expression in term placentas are highly correlated with sex differences in the late first trimester placentas. We found that sex-differential gene expression in the term placenta is significantly correlated with sex differences in gene expression in 42 non-reproductive adult tissues (correlation coefficient ranged from 0.892 to 0.957), with the highest correlation in brain tissues. Sex differences in gene expression were largely driven by gene expression on the sex chromosomes. We further show that some gametologous genes (genes with functional copies on X and Y) will have different inferred sex differences if the X-linked gene expression in females is compared to the sum of the X-linked and Y-linked gene expression in males. Conclusions We find that sex differences in gene expression are conserved in late first trimester and term placentas and that these sex differences are conserved in adult tissues. We demonstrate that there are sex differences associated with innate immune
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Eurovision's Brooke Scullion hoping to show 'new side' of herself on DWTS'We’re going to try to bring lots of fun and energy to the first live show'
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Model who shared steamy kiss with Prince Harry mocks sex confession in new bookIn the book, he reveals he lost his virginity to an older woman, killed 25 Taliban in Afghanistan and claims Prince William assaulted him.
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