New research explored how a protein called tau, critical to Alzheimer's, turns from normal to a diseased state. This discovery presents a new target to potentially prevent or treat this debilitating progressive illness that slowly destroys cognitive function and memory. Alzheimer’s disease is the mo
Scientists have now shown how a critical factor in the development of Alzheimer’s disease, a protein called tau, turns from normal to a disease state – and demonstrates how this discovery could provide a new target for treatment., turns from normal to a diseased state. This discovery presents a new target to potentially prevent or treat this debilitating progressive illness that slowly destroys cognitive function and memory.
Tau accumulates in deposits inside brain cells as Alzheimer’s disease progresses. Tau is highly transformed throughout this process, with various deposits made up of tau bearing multiple minor modifications at many different positions within the tau molecule. “However, we suspected that some of these enzymes are able to target several spots in tau and would do so even more efficiently if tau were already modified at one spot to begin with.”
“By modifying these master sites, we were able to drive modification at multiple other spots within tau, leading to a similar state seen in the brains of Alzheimer’s patients,” says Dr. Ittner. “Tau modification in Alzheimer’s disease is a complicated process. Ours is the first study to link an initial change in tau with multi-site modification along the entire protein.”
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