The researchers are studying the impact of oxidative stress on the aggregation of peptides. Despite significant progress in research, a cure for many age-related diseases, including Alzheimer's, is yet to be found. The accumulation of peptides in the brain, 'clumping,' is one theory for the develop
collaborated to study the association between oxidized cell membranes and peptide aggregation. The results of their research have been published in the journalThe researchers wanted to better understand how cell membranes in the body influence the structure of peptides – these are molecules made up of– and their aggregation. To do this, they used model systems that are easy to control experimentally.
Oxidized model membranes have different effects on peptide fibril formation, driven by membrane surface attraction, peptide charge, and peptide structural properties. Credit: Leipzig University It was already known that membrane composition plays an important role in peptide aggregation. However, there has been little research into the role of oxidized membranes. The researchers found that the effects differ between peptides. One of the peptides studied , which is associated with Alzheimer’s disease, aggregated faster in the presence of all membranes.
Professor Abel explains: “Depending on the peptide’s properties, including its charge, its attraction to the membrane changes, and thus the strength of the influence. If the peptides accumulate on the membrane surface, this accelerates their assembly and aggregation. However, if the attraction is very strong and they change their structure into a helix, then they can no longer aggregate.”
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