The vaccine not only reduced brain inflammation in mice with Alzheimer-like illness, but improved their behavior for the better, the authors say.
The experimental vaccine is being developed primarily by scientists from Juntendo University in Japan., aging cells that no longer divide to make more of themselves, but instead stick around in the body. These cells aren’t necessarily harmful, and some play a vital role in healing and other life functions. But they’ve also been linked to a variety of age-related diseases, including Alzheimer’s.
The team tested their vaccine on mice bred to have brains that develop the same sort of gradual destruction seen in humans with Alzheimer’s. This damage is thought to be fueled by the accumulation of a misfolded form of amyloid-beta, a protein. The mice were divided into two groups, with only one group given the actual vaccine.In the brains of the vaccinated mice, the team found signs of reduced inflammation and fewer amyloid deposits along with lower levels of SAGP-expressing cells.
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