Two newly discovered genes have been linked to schizophrenia while a previously known gene associated with schizophrenia risk has also been linked to autism in a massive new study.
"It's been known that there are genetic components shared among illnesses. Clinically, genes could look different in the same family. The same variant in the same family may cause autism in one family member and schizophrenia in another," Charney"The idea of the same gene having different manifestations is very interesting to us, as it could be useful when it comes to treating people in the clinic.
Sequencing the entire genome is costly, so the researchers applied targeted gene sequencing to carefully selected genes from this data – from 11,580 people with a diagnosis of schizophrenia or schizoaffective disorders, and 10,555 people with no known diagnosis of a psychiatric disorder. The people whose genes were included in the study were not closely related, and 40 percent were non-European.
"Also significant: studying people of various ancestral backgrounds, we found that rare damaging variants in evolutionarily constrained genes confer a similar magnitude of schizophrenia risk among those different populations and that genetic factors previously established in predominantly white people have now been extended to non-whites for this debilitating disease."
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