COVID vaccine effectiveness may be down to genetics, new study suggests.
, initially analysed samples from 1190 participants enrolled in efficacy trials for ChAdOx1 nCov-19, the AstraZeneca/Oxford vaccine. They also examined DNA data from 1677 adults who had enrolled on the Com-COV research programme looking at second-dose options for people who received either the AstraZeneca/Oxford or Pfizer/BioNTech vaccines as a first dose, as well as DNA samples from children who had participated in clinical trials for ChAdOx1 nCov-19.
Dr Alexander Mentzer, group leader at the Wellcome Centre for Human Genetics, at the University of Oxford, and study first author, explained in a Science Media Centre briefing how the gene allele was present in 33.9% of participants reporting symptoms of COVID-19 with a positive swab test for SARS-CoV-2, but that "in the individuals that did not experience breakthrough infection, that were followed up in this study, a large proportion, 45.6%, carried HLA-DQB1*06".
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