The team conducted this study on 233 participants at the Swedish National Study on Aging and Care in Kungsholmen to evaluate different biomarkers for dementia.
Karolinska Institutet researchers have discovered a potential biological marker that could predict the onset of Alzheimer's disease ten years in advance.
They conducted a 17-year study that led to an understanding of "glycan structure in blood." According to the study, the level of glycan can help predict the risk of developing“The role of glycans, structures made up of sugar molecules, is a relatively unexplored field in dementia research. We demonstrate in our study that blood levels of glycans are altered early during the development of the disease.
In this disease, brain neurons begin to die as a result of an accumulation of the proteins amyloid beta and tau. The authors previously demonstrated a link between tau protein and glycan levels in Alzheimer's disease patients. “We also show that a simple statistical model that takes into account blood glycan and tau levels, the risk gene APOE4 and a memory test, can be used to predict Alzheimer’s disease to a reliability of 80 percent almost a decade before symptoms such as memory loss appear,” said Sophia Schedin Weiss, corresponding author.This knowledge could pave the way for the development of simple screening procedures for the better treatment of the individuals impacted by the disease.
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