Targeting a previously undiscovered weakness.
Ahn, a co-corresponding author of the study and a UT Dallas associate professor of chemistry and biochemistry in the School of Natural Sciences and Mathematics,that target protein-protein interactions in cells for more than a decade. Previously, he had developed potential therapeutic candidate compounds for treatment-resistant breast cancer and prostate cancer.
"The ERX-41 compound did not kill healthy cells, but it wiped out tumor cells regardless of whether the cancer cells had estrogen receptors," Ahn said."In fact, it killed the triple-negative breast cancer cells better than it killed the ER-positive cells. Dr. Jung-Mo Ahn, associate professor of chemistry and biochemistry at UT Dallas, synthesized a novel compound called ERX-41 that has shown promise in eliminating cancer cells. Source:Soon, the researchers discovered that ERX-41 binds to lysosomal acid lipase A , a cellular protein. LIPA is found in a cell structure called the endoplasmic reticulum, an organelle that processes and folds proteins.
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