Researchers from WEHI in Australia have discovered a genetic variation present in up to 3% of the global population that heightens the risk of inflammation through a mechanism termed 'explosive' cell death. This study might shed light on why certain individuals have a higher likelihood to develop
Researchers have identified a genetic change in the MLKL gene, carried by 3% of the global population, that intensifies ‘explosive’ cell death, potentially increasing the risk of inflammatory diseases and severe bacterial infection reactions. This discovery may pave the way for improved personalized treatments and insights into individual inflammatory responses.
WEHI’s Dr Sarah Garnish is first author on the paper and said that while there are various types of cell death, necroptosis is distinguished by its ferocity – the cells essentially explode, which sounds an alarm for other cells in the body to respond. Dr Garnish and her co-authors have been able to quantify this at a population level for the first time.
Dr Hildebrand said it’s not as simple as directly connecting this difference in the MLKL gene with the chance of someone developing a specific condition. In the future researchers hope to pinpoint the genetic changes that might mean someone is more likely to have a severe case of, or less likely to bounce back after chemotherapy.
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