Different diseases such as Alzheimer's affect different parts of the brain and lead to dementia - a loss of cognitive functioning to such an extent that it interferes with a person's daily life and activities.
Almost all people who carry two copies of APOE4 are likely to develop signs. READ MORE:Scientists may be one step closer to a cure for Alzheimer’s after working out who is most likely to get the disease.
They found that more than 95 per cent of people aged 65 and above who had two copies of the APOE4 gene went on to show early signs of the disease. They believe this is the first study to show that having two copies of APOE4 almost guarantees the onset of the disease. Around 75 per cent of people have the e2 or e3 varieties, while 20 per cent have one copy of e4 and between 3 and 5 per cent of people have two copies.
Advertisement Dr Juan Fortea, director of the research area on neurological diseases, neuroscience and mental health at the Sant Pau Research Institute, said: 'These data represent a reconceptualisation of the disease or what it means to be homozygous for the APOE4 gene. Dr Reisa Sperling, professor in neurology at Harvard Medical School, and director of the Centre for Alzheimer Research and Treatment at Brigham and Women's Hospital in Boston, Massachusetts, said: 'We have to think about how we can treat APOE4 carriers.'This research really suggests that we should be treating them quite early, at a younger age and at an early stage of pathology because we know they are very likely to progress to impairment quickly.
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