Mice fed a high-sugar, high-fat diet for most of their lives managed to escape weight gain and protect their livers when they were treated with an experimental new drug.
in humans, their method uses long-term dietary stress. Putting the system through short-term dietary stress could help clarify the main effects of MRS2 deletion.
Also, the researchers say that using a complete deletion method for MRS2 makes it impossible to look at how each tissue affects metabolic regulation. Given MRS2's widespread expression, they emphasize the importance of further research into its effects on various organs like the brain, heart, kidneys, lungs, and skeletal muscles.
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