Scientists develop a rapid gene-editing screen to find effects of cancer mutations

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Scientists develop a rapid gene-editing screen to find effects of cancer mutations
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Researchers found a way to screen cancer-linked gene mutations much more easily and quickly than existing approaches, using a variant of CRISPR genome-editing known as prime editing.

Scientists develop a rapid gene-editing screen to find effects of cancer mutations." ScienceDaily. ScienceDaily, 12 March 2024. <www.sciencedaily.com

Researchers have developed a novel genome editing technique known as NICER, which results in significantly fewer off-target mutations than CRISPR/Cas9 editing. The technique uses a different type of ... Prime editing is an improved variant of the CRISPR/Cas system that can introduce alterations in DNA with exquisite precision. But the method is complex and inefficient. A research group has now been ...

A comprehensive study has shown that gene editing, specifically gene knockout , with CRISPR-Cas9 can favor cells with mutated forms of genes linked to cancer. The findings highlight the need to ... Researchers corrected mutations that cause cystic fibrosis in cultured human stem cells. They used a technique called prime editing to replace the 'faulty' piece of DNA with a healthy piece. The ...

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