SARS-CoV-2 detected in white-tailed deer in Canada NaturePortfolio InspectionCan WhiteTailedDeer Deer SARSCoV2 COVID19
By Bhavana KunkalikarNov 14 2022Reviewed by Aimee Molineux In a recent study published in Nature Microbiology, researchers investigated the detection of severe acute respiratory syndrome coronavirus 2 in white-tailed deer.
During the yearly shooting season between 1 November and 31 December 2021, the team sampled 300 white-tailed deer in Eastern and Southwestern Ontario, Canada. Most white-tailed deer in the sample were adults, with equal proportions of males and females. Approximately 213 nose swabs and tissue samples were obtained from 294 retropharyngeal lymph nodes . These were analyzed by reverse transcription polymerase chain reaction for SARS-CoV-2 ribonucleic acid .
Results Out of the 213 nose swabs collected, five tested positive based on the results of two independent RT-PCR analyses conducted at separate institutions. Additionally, 16 RPLNs were validated by PCR. SARS-CoV-2 RNA was found in 21 samples, which accounted for 6% of white-tailed deer harvested by hunters. All SARS-CoV-2 positive animals were adult white-tailed deer found in Southwestern Ontario, with the majority female.
Among the 76 mutations that were similar among the six B.1.641 sequences, nine were in the SARS-CoV-2 spike , while 51 were in the open-reading frame -1ab. The six nonsynonymous mutations in S include five substitutions and a six-nucleotide deletion. These S mutations, except H49Y, evolved before the divergence of B.1.641 lineage from the MRCA shared by the Michigan samples. Furthermore, only a few S mutations were preserved throughout B.1.
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