Review highlights saffron's potential in preventing and treating various human diseases through its bioactive compounds. Clinical and preclinical studies confirm saffron's benefits in conditions like maculopathy, depression, neurodegenerative diseases, and cancer.
By Dr. Sanchari Sinha Dutta, Ph.D.Jul 21 2024 In a review article published in the journal Nutrients , the authors summarized the findings of existing studies investigating the significance of saffron and its by-products in preventing and treating a range of human diseases.
The authors of this review article have searched various scientific databases to identify studies that investigated the preventive and therapeutic potencies of saffron and its by-products. This review includes studies published in English between 1990 and 2024. Bioactive compounds found in saffron leaves include kaempferol and its derivatives, quercetin and its derivatives, luteolin and its derivatives, organic acids, and phenolic compounds.
A clinical trial involving patients with early degenerative maculopathy showed that daily saffron intake can improve visual acuity and slow disease progression. Carotenoids have also been reported to have a positive effect on retinal flicker sensitivity.Saffron's antioxidant, anti-inflammatory, and serotonergic properties have made it a strong, natural antidepressant.
Crocin and crocetin have been found to inhibit amyloid-beta peptide aggression and delay synaptic loss, leading to neuroprotection against Alzheimer's disease-related cognitive deterioration.
Alzheimer's Disease Antifungal Anti-Inflammatory Antioxidant Anxiety Apoptosis Blood Cancer Cell Chronic Chronic Kidney Disease Clinical Trial Compound Cosmetics Depression Diabetes DNA Food Glucose Inflammation Kidney Kidney Disease Medicine Metabolic Syndrome Neurodegenerative Diseases Nutrients Oxidative Stress Quercetin Serotonin Spice Stress Syndrome
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