RSV vaccines for older adults: 2023 ACIP recommendations VUBasicSciences DrexelMedicine harvardmed CDCgov vaccine vaccination RSV RespiratorySyncytialVirus virus
By Vijay Kumar MalesuAug 1 2023Reviewed by Sophia Coveney A recent report published in Morbidity and Mortality Weekly Report provided clinical guidance on Respiratory syncytial virus vaccines for adults ≥60 years, with moderate to high efficacy in preventing severe respiratory illness and the potential to reduce morbidity and mortality.
They also assessed safety by looking into inflammatory neurologic events, such as Guillain-Barre syndrome and acute central nervous system inflammation occurring within 42 days of vaccination. The vaccine showed 82.6% efficacy during the first season and 56.1% during the second season in preventing RSV-associated LRTD. The study demonstrated a 74.5% efficacy in preventing LRTD and a 77.5% efficacy in preventing clinically attended RSV-associated LRTD over two seasons.
Pfizer vaccine The Pfizer RSV vaccine’s efficacy data were obtained from an ongoing phase 3 clinical trial involving 36,862 immunocompetent individuals aged ≥60 years in multiple countries. The trial analyzed data collected from August 2021 to January 2023, covering one complete RSV season for both southern and northern hemisphere individuals and a partial second season for individuals of Northern hemisphere.
Additionally, three inflammatory neurologic events were reported in participants who received the vaccine, including Guillain-Barre syndrome, Miller-Fisher syndrome, and undifferentiated motor-sensory axonal polyneuropathy.
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