The victory, with goals from Diogo Dalot and Marcus Rashford adding to Ronaldo's strike, guaranteed the Red Devils a place in the next round, where they will join Barcelona who were knocked out of the Champions League at the group stage 24 hours earlier.
PARIS - Cristiano Ronaldo scored on his first Manchester United appearance since his refusal to come on as a substitute last week in a 3-0 win over Sheriff Tiraspol in the Europa League on Thursday.
Right-back Dalot opened the scoring just before the break before Rashford doubled the lead with 25 minutes to play.Arsenal, who have already reached the last 16, lost for the first time in the group stage as they went down to a 2-0 defeat at PSV Eindhoven. Surprise early season Bundesliga leaders Union Berlin kept alive their hopes of a place in the knockout round of the second-tier European competition thanks to a 1-0 win over Braga.
In their first match since coach Unai Emery announced he was leaving to manage Premier League club Aston Villa, Villarreal dropped points for the first time in Europe this season.