The chart-topping singer was fined £10,000 for breaking Covid lockdown restrictions back in 2020.
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Two Buchanan Street buildings hit the market for nearly £10 millionTwo properties located on Glasgow's busiest shopping street have been put up for sale and there are only plans in place to develop the upper parts into residential units.
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Two properties for sale on Glasgow's busiest shopping street for almost £10 millionPlanning has been approved for the development of 14 flats on the upper floors 🔨
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Holly Willoughby hails £10 concealer which is 'incredibly eye-brightening'Holly said: 'I’ve perfected my wake-up/makeup routine over the years to refresh my face, body (and mind) ahead of going LIVE to the nation most mornings'
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WATCH: Mass. Officials Discussing End of COVID Health EmergencyAs the end of the COVID-19 public health emergency approaches, Massachusetts health officials on Tuesday are expected to deliver remarks about what to expect. Mass. Department of Public Health Commissioner Dr. Robert Goldstein and Medical Director for DPH’s Bureau of Infectious Disease and Laboratory Sciences Dr. Larry Madoff are expected to speak at 1 p.m. on Tuesday about the end…
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Murder trial teacher claims relationship ‘deteriorated’ after Covid lockdownFiona Beal, 49, of Moore Street, Northampton has been giving evidence
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Target-agnostic drug prediction integrated with medical record analysis uncovers differential associations of statins with increased survival in COVID-19 patientsAuthor summary Retrospective studies have shown that COVID-19 patients taking HMGCR-inhibiting statins exhibit a reduced risk of mortality. However, potential variability in statin effects has been detected and studies from diverse sub-fields also suggest that this seemingly homogeneous class of compounds may function differently despite close chemical similarity. Based on predictions of a computational drug repurposing algorithm in combination with clinical evidence gathered during the COVID-19 pandemic, we identified that different statin types appear to have different biological properties despite similar chemical structure and they vary in their association with increased survival in COVID-19 patients. Together, in silico predictions from patient transcriptomics data, in vitro assays of infection, cytotoxicity, and host response, and retrospective clinical data provide a more comprehensive assessment of individual statin activity. Our findings, along with other emerging data, suggest that some statins (i.e., simvastatin, atorvastatin, and rosuvastatin), but not others, have a mitigating effect on the severity of COVID-19 disease reflected in a reduction in mortality. Importantly, different statins seem to exert different biological activities despite similar chemical structure and shared known mechanism of action related to lipid metabolism. These findings suggest that drug repurposing efforts may require consideration of drug-specific effects rather than accepted mechanisms.
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