Researchers provide insight into the interaction between T lymphocytes and persisting reservoirs of HIV, with repercussions for harnessing effective, long-lasting responses to HIV eradication.
By Pooja Toshniwal PahariaSep 14 2023Reviewed by Danielle Ellis, B.Sc. In a recent preview published in Cell Host & Microbe, researchers provide insight into the interaction between T lymphocytes and persisting reservoirs of the human immunodeficiency virus , with repercussions for harnessing effective, long-lasting responses to HIV eradication.
Impact of antiretroviral therapy on HIV-targeted T lymphocyte repertoire HIV-targeted T cells can be referred to as "latent reservoirs" in individuals on ART; however, this view ignores underlying difficulties. Despite being mostly short and ineffective, HIV transcripts are ubiquitous throughout ART. Although most of the viral-infected cells are "latent," they may still be detectable by T lymphocytes, which may identify trace levels of antigen.
The frequency of vRNA+ cells was strongly proportional to the length of pre-ART infection, offering a possible hint to their formation and maintenance for future research. While a median of four percent of the cells with incorporated HIV deoxyribonucleic acid spontaneously generated viral RNA, it was mostly abortive or short, with only a few cells producing p24 protein.
The findings showed that cells infected with the human immunodeficiency virus on ART that are transcriptionally active generate antigens that preserve a functioning cytotoxic T lymphocyte reaction.
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