A three-year-long study has tracked dozens of patients with an ultra-rare disorder that gradually turns muscle, tendons, and ligaments to bone.
This mutation occurs in a gene that codes for a receptor regulating bone development, seeming to causeGiven the severity and rarity of FOP, it's hoped the findings of the current research will allow doctors to better meet the medical needs of underserved patients.
Not everyone with FOP shows the same rate of calcification, but once bone is laid down in a part of the body, it is permanent. Most people require a wheelchair by the age of 20. The recent long-term study is among the first to really delve into the progression of FOP among 114 patients. Previous studies on the one-in-a-million disorder have merely been retrospective in nature or based on patient reports.
Even though FOP's progression seems to slow with age, 70 percent of individuals aged 25 to 65 years showed new bone volume at an annual study check-up.
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