Researchers target lifecycle of parasite behind Chagas disease

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Researchers target lifecycle of parasite behind Chagas disease
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Almost everything about insects called kissing bugs is revolting, from the insidious way they bite people's faces at night to drink their blood while they sleep to the way they spread disease through their poop.

Some carry a parasite called Trypanosoma cruzi that causes Chagas disease, a leading cause of disability and premature death in the Americas. Left untreated, Chagas disease can cause serious heart and digestive problems. It's showing up more and more in patients in the United States.

In her molecular parasitology lab at UC, Lander and her research team examined the ways T. cruzi survives in different hostile environments. They deployed technology such as the gene-editing tool CRISPR/Cas9, immunofluorescence analysis and electron microscopy for the study. , or cAMP, is responsible for the parasite's life cycle transformations in response to environmental stress.

"It's a chronic disease that mainly affects poor people in these countries with no access to treatment," Chiurillo said.

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