To learn more about what causes the body to reject biomedical implants, a team has identified a protein that appears to help drive this response and hopes their discoveries will improve the design and safety of biomedical implants.
To learn more about what causes the body to reject biomedical implants, a team at the University of Arizona College of Medicine -- Tucson identified a protein that appears to help drive this response and hopes their discoveries will improve the design and safety of biomedical implants.
"When we examined the severe fibrotic samples, RAC2 was one of the most important proteins we found," Chen said."Because it seemed to drive a lot of downstream pathways, we decided to explore a little more closely." "We targeted RAC2 along with other pathways and observed a significant reduction in the level of FBR -- up to three-fold," said Dharshan Sivaraj, research fellow in the Department of Surgery and co-lead author of the study."We think targeting these pathways could serve as a potential therapy to mitigate or even prevent clinically significant FBR in humans."
Tech Launch Arizona, the University of Arizona's technology commercialization office, is working with the team to translate the innovation from the laboratory to the marketplace, where they hope it will have real-world impact for patients and their health care providers.
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