Professor Huang Hanmin's research team from the University of Science and Technology of China (USTC) of the Chinese Academy of Sciences (CAS) proposed a new paradigm of metal electron-shuttle catalysis, which has been pioneeringly employed to achieve alkylative aminomethylation of unactivated alkene for the first time. Their work was published in Nature Catalysis on August 21.
, thereby facilitating the construction of complex molecules. Existing research is often limited to the introduction of C functional groups, or they require the pre-installation of coordinating groups onto the alkenes to stabilize the alkyl-metal intermediates. This undeniably reduces the substrate applicability and step economy of the reaction.
In this study, the team employed a nickel catalyst as the electron shuttle and used N, O-acetals and alkyl halides as the alkylating agents to accomplish the dialkylation of unactivated alkenes. This method demonstrated excellent compatibility with simple alkenes, unactivated alkenes and polysubstituted alkenes.
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