Red blood cell hitch-hiking facilitates SARS-CoV-2 multi-organ spread medrxivpreprint UBARectorado redbloodcells SARSCoV2 COVID19 covid research healthresearch news
By Pooja Toshniwal PahariaApr 3 2023Reviewed by Lily Ramsey, LLM *Important notice: medRxiv publishes preliminary scientific reports that are not peer-reviewed and, therefore, should not be regarded as conclusive, guide clinical practice/health-related behavior, or treated as established information.
About the study In the present study, researchers investigated the association between viral organotropism and clinical manifestations employing the prototypical CoV in the naturally occurring host, the murine hepatitis virus -A59 model. Kidney, heart, lung, and liver tissues were obtained from autopsies performed on eight individuals with COVID-19-associated deaths. BALB/cJ mice were used for the in vivo experiments, infected with MHV by intraperitoneal injection, and treated with hemin and chloroquine, individually and in combination.
Of note, SARS-CoV-2 ribonucleic acid was detected in the kidneys and heart of individuals, in addition to in the lungs of individuals deceased due to COVID-19. MHV infection significantly reduced the weight of infected mice, and SARS-CoV-2 RNA was most abundant in mice's lungs, liver, spleen, and brain. SARS-CoV-2 particles, obtained from various organs, were infectious, as determined by the viral infectivity assays.
South Africa Latest News, South Africa Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Study indicates interspecies transmission of SARS-CoV-2 between humans and their pets occurs regularlyStudy indicates interspecies transmission of SARS-CoV-2 between humans and their pets occurs regularly VirusesMDPI Loeffler_News covid COVID19 SARSCoV2 zoonotic disease immunology news pet dogs interspecies
Read more »
Researcher hypothesizes that overnutrition could lead to loss of self-tolerance by impinging on immune regulationResearcher hypothesizes that overnutrition could lead to loss of self-tolerance by impinging on immune regulation ScienceMagazine UninaIT obesity immunity immuneregulation overnutrition nutrition health
Read more »
Is there an association between ultra-processed food consumption and depressive symptoms?Is there an association between ultra-processed food consumption and depressive symptoms? tandfonline ucl univpaulvalery Deakin processedfood foodnews nutrition health depression ultraprocessed medical
Read more »
Using AI to enhance the performance of surgeons: decoding intraoperative surgical activity via accurate machine learning systemsUsing AI to enhance the performance of surgeons: decoding intraoperative surgical activity via accurate machine learning systems natBME Caltech USC surgery AI artificialintelligence machinelearning surgical
Read more »
Growth trajectories among infants with vs without in utero COVID-19 exposureGrowth trajectories among infants with vs without in utero COVID-19 exposure MassGeneralNews harvardmed COVID19 coronavirus covid children infants babies
Read more »
What F1 GPS data reveals about Mercedes' threat to Red Bull in AustraliaMercedes surprised itself, let alone Formula 1\u2019s audience and the rest of the paddock, with a sudden revival in time for qualifying ahead of the 2023 Australian Grand Prix.
Read more »