Were you or a loved one recently diagnosed with Parkinson's disease? New research indicates that the disease may have been progressing quietly but insidiously for more than 10 years. This study, conducted at the University of Montreal and published in the journal Nature Communications, provides n
New research reveals that the brain’s movement circuits are surprisingly resilient to the loss of dopamine, a chemical crucial for movement, in the asymptomatic period of Parkinson’s disease. The study found that mice showed normal movement capacity despite almost no active dopamine secretion, suggesting that only low basal levels of dopamine are needed for brain activity, and symptoms of Parkinson’s appear when a minimum threshold is exceeded.
This observation is surprising because dopamine is a chemical messenger recognized for its importance in movement. And in Parkinson’s disease, dopamine levels in the brain drop inexorably. As a doctoral student in Trudeau’s laboratory, Benoît Delignat-Lavaud expected to see a loss of motor function in these mice similar to what is seen in individuals with Parkinson’s.Meanwhile, measurements of overall dopamine levels in the brain, carried out by UdeM trauma specialist Louis de Beaumont’s team at the Centre de recherche de l’Hôpital du Sacré-Cœur de Montréal, revealed that extracellular levels of dopamine in the brain of these mice were normal.
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