Primary vaccinations and boosters effective in reducing COVID-19 severity during Delta and Omicron predominance

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Primary vaccinations and boosters effective in reducing COVID-19 severity during Delta and Omicron predominance
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Primary vaccinations and boosters effective in reducing COVID-19 severity during Delta and Omicron predominance JAMA_current UNC SARSCoV2 COVID19 Booster PrimaryVaccination Vaccine Delta Omicron Variant

By Dr. Chinta SidharthanSep 29 2022Reviewed by Aimee Molineux In a recent study published in the Journal of the American Medical Association, researchers analyzed coronavirus disease 2019 vaccination and surveillance data to understand the effect of primary vaccinations, boosters, and prior severe acute respiratory syndrome coronavirus 2 infections on severe COVID-19 outcomes and subsequent infections.

About the study In the present study, the researchers analyzed COVID-19 surveillance data from North Carolina between March 2 and June 3, 2022, which contained laboratory-reported polymerase chain reaction and antigen test results, and information on demographics and clinical outcomes. The vaccination history data from December 11, 2020, to June 3, 2022, was procured from the COVID-19 vaccine management system records. The cohort study consisted of data for 10.6 million North Carolina residents.

Related StoriesThe second section of the analysis estimated booster effectivity in individuals with complete primary vaccinations. The waning effect of the booster vaccination on each outcome was calculated by incorporating the time elapsed since the booster vaccination into the analysis. The association of six common combinations of boosters and primary vaccines on COVID-19-related hospitalization and death was analyzed.

Prior SARS-CoV-2 infections reduced the risk of reinfections, hospitalization, and death, but the protective effects diminished with time. Booster vaccines increased protection against infection and severe outcomes in primed individuals with and without previous infections.

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