Loss of Menin helps drive the aging process, and dietary supplement can reverse it in mice. Cognition, bone mass, skin thickness, and lifespan are all affected by Menin’s decline. According to a new scientific study, the decline in the hypothalamic Menin may play a key role in aging. The findi
The decline of Menin in the hypothalamus may contribute to physiological aging, affecting cognition, bone mass, skin thickness, and lifespan. A recent study using mice suggests that a simple dietary supplement of an amino acid may help mitigate some of these age-related changes.Cognition, bone mass, skin thickness, and lifespan are all affected by Menin’s decline.
Researchers find that the loss of a hypothalamic hormone helps drive the aging process, and a supplement can help reverse it in mice. Credit: Lige Leng, Ziqi Yuan and Jie Zhang, 2023, PLOS Biology,Recently, Leng and colleagues showed that Menin, a hypothalamic protein, is a key inhibitor of hypothalamic neuroinflammation, leading them to ask what role Menin may play in aging. Here, they observed that the level of Menin in the hypothalamus, but not astrocytes or microglia, declines with age.
Could reversing age-related Menin loss reverse signs of physiological aging? To test that, the authors delivered the gene for Menin into the hypothalamus of elderly mice. Thirty days later, they found improved skin thickness and bone mass, along with better learning, cognition, and balance, which correlated with an increase in D-serine within the hippocampus, a central brain region important for learning and memory.
Nonetheless, Leng said, “We speculate that the decline of Menin expression in the hypothalamus with age may be one of the driving factors of aging, and Menin may be the key protein connecting the genetic, inflammatory, and metabolic factors of aging. D-serine is a potentially promising therapeutic for cognitive decline.”
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