Researchers analyzed systematic reviews conducted on the association between autoimmune diseases and pregnancy outcomes.
By Pooja Toshniwal PahariaMar 8 2024Reviewed by Danielle Ellis, B.Sc. In a recent review published in BMC Medicine, researchers analyzed systematic reviews conducted on the association between autoimmune diseases and pregnancy outcomes.
About the review In the present review, researchers analyzed the impact of autoimmune disease prevalence on pregnancy outcomes, using systematic reviews to identify the strength and precision of these associations. The team evaluated systematic review quality using the Newcastle-Ottawa scale . They synthesized data quantitatively to estimate relative risks and odds ratios and performed random effect modeling for meta-analysis to obtain pooled effect estimates.
The team found increased miscarriage risk among females with systemic lupus erythematosus and Sjögren’s syndrome , with the risk being higher in the case of thyroid autoimmune conditions. Miscarriage risk was also significantly higher among women with celiac disease, rheumatoid arthritis, systemic sclerosis, and psoriasis, with OR values of 1.4, 1.3, 1.6, and 1.1, respectively.
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