Photobiomodulation in sleep has more therapeutic effects for Alzheimer's disease than in wakefulness

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Photobiomodulation in sleep has more therapeutic effects for Alzheimer's disease than in wakefulness
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It is well known that sleep is the best medication. However, it is still unknown why the brain recovers better in sleep and whether these processes can be controlled.

Reviewed by Megan Craig, M.Sc.Sep 22 2023 Recent discoveries have shown that the lymphatic system of the brain is activated during sleep, which contributes to the removal of metabolites, toxins and unnecessary molecules from its tissues. Sleep disturbance contributes to the deposition of metabolites in the central nervous system . For example, sleep is a biomarker for the development of Alzheimer's disease.

In this pilot study, the researchers have shown that non-invasive sleep photobiomodulation technology can effectively increase lymphatic excretion of beta-amyloid from the brain tissues of mice with Alzheimer's disease. At the same time, photobiomodulation in sleep has more significant therapeutic effects than in wakefulness.

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