Phenotype-tailored lifestyle interventions show promising weight loss results in obese adults obesity weightloss lifestyleinterventions phenotype clinicaltrial healthresearch cardiometabolic behaviorchange nutrition physicalactivity eClinicalMed
By Dr. Priyom Bose, Ph.D.Apr 16 2023Reviewed by Benedette Cuffari, M.Sc. Obesity is a chronic multifactorial disease, which is increasing globally at an alarming rate.
Background Related StoriesLifestyle interventions play a significant role in weight management, which commonly includes the consumption of a low-calorie diet, along with moderately intense physical activity. To date, no specific diet has been designed specifically for weight loss. Based on behavioral and pathophysiologic characteristics, obesity phenotypes have been categorized into hedonic eating behavior, homeostatic eating, and abnormal energy expenditure. To date, researchers have yet to determine whether diet and lifestyle interventions customized to these phenotypes could yield a better outcome as compared to standard lifestyle interventions.
The study was divided into two phases. Individuals who were associated with the first phase received the standard lifestyle intervention , whereas those in the second phase were subjected to phenotype-tailored lifestyle intervention . Study findings A total of 211 participants were screened, 81 of whom received SLI, and 84 were subjected to PLI. About 88.5% of the participants made it to the 12-week weight assessment. Most of the participants were women, white, with an average age of approximately 43 years.
These observations suggest that PLI is more beneficial in people with obesity or obesity-related comorbidities. Notably, the PLI group exhibited improvements in abnormal satiation and emotional eating related to obesity.
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