Pfizer’s own study suggests the bivalent shot may induce a higher level of protection against the Omicron BA.4 and BA.5 sublineages than the original vaccine
fizer said its bivalent vaccine bolstered protective antibodies against the dominant Omicron strains substantially more than its original booster in people older than 55 years old, suggesting the new booster may provide an enhanced level of protection.
The Pfizer-BioNTech finding contrasts sharply with recent results from two independent labs at Columbia University and Harvard University. Both of those teams reported in October that bivalent boosters made by Pfizer and rival Moderna didn’t appear to provide much incremental benefit when compared with a fourth dose of the original vaccines, according to studies posted on the preprint server bioRxiv.org.
It is not clear why various studies have produced what appear to be divergent results. All of the studies are small and have not yet been published in scientific journals.
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