Perspective | The search for chloroquine helped bring about the modern pharmaceutical industry

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Perspective | The search for chloroquine helped bring about the modern pharmaceutical industry
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Perspective: The search for chloroquine helped bring about the modern pharmaceutical industry

showing that death rates are higher in covid-19 patients who were treated with hydroxychloroquine, the drug Trump touted.

But back then, U.S. drug companies were tiny compared with today’s giants. Some made no more than quack cures and remedies. The skills of U.S. chemists were limited by lack of experience. And most malaria experts knew little about drug development; they studied the mosquitoes that carry malaria.The Germans were by far the best at drug making. Bayer Co. — with blockbusters such as aspirin and heroin — set out to make a malaria drug after the disease crippled troops in World War I.

For three years, these scientists unsuccessfully ran tests on compounds that killed thousands upon thousands of chicks and ducklings with bird malaria, hundreds of dogs in toxicity tests and many, many human subjects.Just as Bayer had done in Germany in the 1920s and 1930s, U.S. researchers experimented on syphilitics undergoing malaria therapy at state hospitals in Massachusetts, Georgia, South Carolina, Illinois, New York and Washington, D.C.

We know this drug is particularly dangerous in people with heart, eye, liver and kidney problems, which are found so commonly in the elderly. So those who tend to become the sickest with covid-19 are the very people most susceptible to the dangers of chloroquine.

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