I am a senior reporter for the Forbes breaking news team, covering health and science from the London office. Previously I worked as a reporter for a trade publication covering big data and law and as a freelance journalist and policy analyst covering science, tech and health.
Ozempic Maker’s New Weight Loss Pill Beats Wegovy In Early Trial — What To Know About Novo Nordisk’s Amycretin
Ozempic maker Novo Nordisk on Thursday teased a potential successor to its blockbuster weight loss drug Wegovy, the latest in a line of next-generation obesity treatments in development as consumers flock to the powerful drugs and competitors including Eli Lilly, Pfizer and an array ofdata from an early stage clinical trial of an experimental weight loss drug called amycretin, an oral treatment that trial results suggest could be more powerful than the company’s popular weight loss drug Wegovy.
The pill, taken once a day, helped patients in the trial drop 13% of their weight over 12 weeks, a more impressiveAmycretin effectively combines the functionality of two different drugs into a single molecule that targets two hormones involved in regulating hunger and blood sugar levels: GLP-1 and amylin.
GLP-1 is the same hormone targeted by semaglutide and tirzepatide—generic names for Novo and Lilly’s diabetes and obesity blockbusters Ozempic, Wegovy, Mounjaro and Zepbound—and companies including Novo andNovo is also testing a subcutaneous form of amycretin delivered through regular injections like Wegovy and Zepbound, though the early stage trial is ongoing and data is not expected to be released until around 2025.
Novo’s head of development Martin Lange Holst said the promising trial results justify further research into the pill and that a larger Phase 2 trial would begin in the second half of the year.It will still be many years before Novo’s amycretin hits pharmacy shelves. Data from the mid-stage trial will not be available until around 2026, at the earliest, and regulators are likely to want an even more comprehensive trial to assess efficacy and safety to authorize it.
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