The service is carrying passengers between Didcot Parkway train station and Milton Park.
The bus company's head of policy called it "revolutionary".
First Bus said the bus' radar, LiDAR and AI technology could safely steer, accelerate and brake without the need for human intervention.They are also on board to "provide a personalised service and information to passengers".The company previously ran trials with a mini-bus, saving 1.5 tonnes of carbon
The 28-seater bus began operating on Thursday and will run every 30 minutes from 07:00 to 18:30 Monday to Saturday until the trial's conclusion on 30 September. Head of policy John Birtwistle said First Bus was "leading the way" and bringing an "innovative and green approach to the future of public transport".
He added: "The next phase in this ground-breaking bus service gives us the opportunity to show more customers the exciting possibilities afforded by combining zero emission and digital autonomous technology to provide a smarter, cleaner and quieter way to travel."Milton Park is a science, technology and business community in Oxfordshire, with more than 270 companies and 9,000 employees.
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