Overall patterns of SARS-CoV-2 caused by variants of concern among children and adolescents medrxivpreprint UniBasel_en unibern institutpasteur sheffielduni SARSCoV2 covid coronavirus covid variantsofconcern childhealth teenagers
By Tarun Sai LomteJan 17 2023Reviewed by Danielle Ellis, B.Sc. A recent study posted to the medRxiv* server systematically reviewed coronavirus disease 2019 among adolescents and children due to severe acute respiratory syndrome coronavirus 2 variants of concern .
Data on study design, population, setting, outcomes, age groups, publication characteristics, and prevalent VOCs were extracted by one reviewer and verified by another. The risk of bias was assessed using published tools, and the relevance and credibility of modeling studies were evaluated using a published checklist.
No symptom could be consistently attributed to a particular VOC, and the symptom frequencies due to VOCs were not different from the pre-VOC period. The incidence of croup cases increased during the Omicron wave relative to the pre-Omicron period. None of the included studies explored symptoms due to the Beta variant.
One study compared the risk factors for severe COVID-19 due to infection with Delta or Omicron in adolescents/children. It reported that individuals under 18 with at least one comorbidity were at a higher risk for moderate/severe disease due to infection with Omicron but not Delta. Another study reported a higher risk of severe COVID-19 in children aged 5 – 11 with obesity or diabetes.
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