Cancercells may sense immune surveillance and actively adapt elife elife
for the benefit of readers; feedback on the manuscript for the authors, including requests for revisions, shown below. We also include an acceptance summary that explains what the editors found interesting or important about the work.Thank you for submitting your article"Optimal Cancer Evasion in a Dynamic Immune Microenvironment Generates Diverse Post-Escape Tumor Antigenicity Profiles" for consideration by.
2) The process of Clonal cancer evolution should be better discussed in relation to the model, which describes the dynamics of mutations but does not follow clones. The idea that cancer can sense and respond to the immune system and the tumor microenvironment is exciting and intriguing but therefore requires stronger evidence. It would be valuable to make more connections to known observations to support this type of model. This is especially true since some of the model"predictions", like the correlation between lower immune surveillance and tumor mutational burden, are known from simpler principles.
To start with, I had a hard time following some of the terminology. There are some instances where different terms are used to refer to the same concept. For instance, in Figure 1C the terminology changes between the legend and plot . Furthermore, the terminology seems overloaded: π is referred to as an evasion probability, but maybe one would want to reserve this term for the complete evasion of immune recognition by cancer.
Following the reviewers’ suggestions, we have made several significant changes to the manuscript to clarify the underlying assumptions. First, we have changed the language describing the evasion probability and the rate of Tumor-Associated Antigen loss . We have also re-structured the presentation of the evasion penalty to separate out the decision-dependent of Immunoediting’.
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