Olokizumab vs. adalimumab for RA: Phase 3 results RheumTwitter rheumatoidarthritis
The investigational IL-6 inhibitor olokizumab fared better than placebo and was noninferior to the tumor necrosis factor inhibitor adalimumab in patients with moderate to severe rheumatoid arthritis who’d had an inadequate response to methotrexate alone, according toThe results from the phase 3, multicenter, double-blind, parallel-group, randomized, placebo- and active-comparator–controlled trial, called, add to the evidence base on the drug, which was developed by R-Pharm in Russia and has...
“Previously studied anti–IL-6 antibodies and anti–IL-6R antibodies prevent binding of IL-6 to the IL-6R,” he said. “Moreover, the amount of protein needed to inhibit IL-6 is lower compared to the approved antireceptor antibodies. Olokizumab has also been shown to be effective when given every 4 weeks in many patients, compared with the need for weekly or every-other-week applications with tocilizumab and sarilumab.
Dr. Smolen noted that there are three binding sites for IL-6, but olokizumab is the first to target site 3, the binding site for GP130. Mortality concerns haven’t been seen for olokizumab. There were three serious adverse events leading to death in the olokizumab every-2-weeks group; two in the olokizumab every-4-weeks group; one in the adalimumab group; and one in the placebo group.
While Dr. Emery said it was important that no bad safety signal has been seen, he noted that “it’s a short-term study, and you do need to see the long-term data.”
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