I am a scientist, businessman, author, and philanthropist. For nearly two decades, I was a professor at Harvard Medical School and Harvard School of Public Health where I founded two academic research departments, the Division of Biochemical Pharmacology and the Division of Human Retrovirology.
developed to treat cancer. T cells , part of the body's immune system, are taken from the patient and have their DNA modified by viruses so that they produce chimeric antigen receptor proteins. These proteins will be specific to the patient's cancer. The modified T cells are then multiplied in the laboratory before being reintroduced to the patient.Just as we age, so do our cells.
The threat of these cells is that the inflammation they cause spreads and begins to damage otherwise healthy cells — much like a wildfire starts with a small spark in a dry forest.Our immune system has a very clear function: to locate and eradicate any microbial threats or dysfunctional cells, including cancerous cells and senescent cells. To this end, it comes equipped with an extensive quiver of “tools”, or immune cells.
The idea behind chimeric antigen receptor -T cell therapy is to leverage this destructive power of killer T cells to target and eliminate cells that are otherwise overlooked by the immune system. For example, even though cancerous cells are a risk to us, they are often “too close to home”; our killer T cells simply do not recognize them as a threat. To remedy this, researchers pioneered a novel approach.
In theory, the search-and-destroy function of CAR-T cells could also be used for the elimination of other dysfunctional cells that fly under the radar, like senescent cells.To determine whether CAR-T technology could be used to eliminate senescent cells, the group of scientists engineered CAR-T cells that home in on Natural Killer Group 2 Member D ligands, which, they discovered, are found in high numbers on senescent cells.
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