Many breast cancer survivors take a hormonal drug after cancer treatment to stave off a recurrence, but new research suggests these drugs may be less effective in women who are obese.
are fueled by the female sex hormone estrogen. Aromatase inhibitor medications lower estrogen levels by stopping an enzyme in fat tissue called aromatase from changing other hormones into estrogen.were 18% more likely to have a recurrence even when taking an aromatase inhibitor, and this increased risk was even higher among survivors who were severely obese, the investigators found.
However, he added, “Treatment with aromatase inhibitors is still the treatment choice for this patient group and lowers the rate ofFat cells store estrogen, and women who are obese have more fat tissue, which could explain why aromatase inhibitors are less effective at suppressing estrogen in these women.and were taking aromatase inhibitors to prevent a recurrence. Of these, there were 1,587 recurrences that took place during slightly more than six years of follow-up.
“Fortunately, unlike genetics and other risk factors, body weight is modifiable and highlights the importance of programs which incorporate “This can empower women to play a critical role in reducing their risk of breast cancer recurrence," Calfa added.
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