Obesity in pregnant women could alter structure and function of placenta, raising poor health outcome risk ThePhySoc
The rates of obesity and GDM, the development of poor glucose handling during pregnancy, are increasing worldwide. Both are linked to multiple maternal and fetal complications, such as increased risk of fetal death, stillbirth, infant death and higher infant birth weight. It is not known how these complications arise., more than GDM, reduced the formation of the placenta, its blood vessel density and surface area, and its capacity to exchange nutrients between the mother and developing child.
The study looked at 71 women who were black or of mixed ancestry. Of those, 52 were obese and 38 had developed GDM. The researchers conducted the study using clinical profiling, deep structural examination and molecular analysis of the placenta, and biochemical measurements of maternal and infant cord blood to examine the effect of obesity and GDM in this group of expectant women.
Lead author Professor Amanda Sferruzzi-Perri of the University of Cambridge said,"For the first time we have looked at the effects of both obesity and GDM on the placenta in black and mixed-ancestry woman, who are an understudied group, and what effect that these conditions might have on them and their children. It was important to discover that obesity has more of an influence than GDM on pregnancy outcomes for both the mother and the child.
Lead co-author Professor Mushi Matjila of the University of Cape Town said,"South Africa is burdened by a quadruple disease burden of communicable and non-communicable disease, along with high maternal and child morbidity and mortality, and deaths related to violence and injuries. Additionally, we have one of the highest rates of female obesity globally, which undoubtedly fuels the non-communicable disease burden and contributes to maternal, neonatal and child morbidity.
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